Associate Director Physician – Translational Science (Oncology)

Cambridge, England, UK
25 Jun 2017
30 Jul 2017
Career Level
Contract Type
Full Time

Associate Director Physician – Translational Science (Oncology)
Clinical Development

Locations: Cambridge, UK
Salary: Very competitive with excellent benefits

Ongoing investment in our industry-leading early oncology development pipeline has opened an exciting opportunity within our Innovative Medicines Translational Science (Oncology) function. This position will be based in our oncology R&D site in Cambridge, UK.

This position is unique in that it includes a rotational element: initially you will join as an Associate Director Physician in Translational Science, but with the intention of moving, after delivery of a significant piece of work (over an expected 2-year timescale), to the Oncology Translational Medicine Unit as an Associate Director Physician, or a Director Physician.

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

We are leaders in science and medicine, pushing the boundaries of what is possible every day.  That’s why we have cultivated an environment of excellence and open global collaboration, together with a strong track record of publications.  Our entrepreneurial spirit gives our scientists and clinicians the courage to take smart risks and not be discouraged by failure - we empower our people to not only keep abreast of the latest developments and breakthroughs, but to drive them.

It is our mission to lead the right molecules into the clinic, determine the right doses and exposures for those molecules, in the right patient populations, whilst ensuring we do so to the highest scientific and clinical standards.  Our talented people lead this important work by designing and delivering innovative clinical studies, integrating data, informing research and development, and accelerating target validation.  Putting patients first, and safely and ethically pursuing opportunities where we will have a truly positive impact on healthcare in areas of major unmet need is core to our value set.

Ours is the place where science meets the patient.  We work closely with our colleagues in Bioscience, Discovery Sciences, Drug Safety and Metabolism, Pharmaceutical Sciences and Personalised Healthcare and Biomarkers amongst others, on drug target identification, lead optimization and candidate drug selection, and across the early phases of small molecule clinical drug development in oncology through to the end of Phase 2 and determination of proof of concept.

By building a diversity of expertise and experience in the oncology Translational Medicine Unit, it is our intention to create a global centre of excellence at AstraZeneca in pharma training for oncologists joining the industry.

In your initial role in Translational Science you will:

  • Develop biomarker strategies based on the best available science and technology, and ensure their application and delivery in clinical studies.
  • Generate disease linkage data to guide selection of specific disease indications, and the selection of targeted patient populations within those indications.
  • Measure drug target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules for further clinical investigation.
  • Understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combination strategies.
  • Determine mechanisms of resistance to targeted therapies by studying tumours at relapse.

In your subsequent role in the Oncology Translational Medicine Unit you will:

  • Be part of a cross-functional clinical development study team of experienced drug developers that is formed around each candidate molecule to drive its development.
  • Be integral to the design, conduct, monitoring, data interpretation, reporting and publication of specific clinical studies within the early clinical development portfolio for that project.
  • Be agile, pioneering and collaborative in your position as the key contact for specific clinical studies, ensuring the ethical and scientific integrity of all activities, and in compliance with Good Clinical Practice and all relevant regulatory requirements.
  • Create personal networks within AstraZeneca, and draw upon our world-class, specialist early oncology development community to ensure peer-reviewed and collaborative clinical input into translational science, personalised healthcare and biomarker, quantitative clinical pharmacology, bioinformatics and other development-related strategies to assure the very highest standards of quality, and scientific and clinical validity.
  • Be actively internally and externally facing, including detailed interactions with regulatory agencies, ethics committees, clinical investigators, site staff and study monitors, disease area thought leaders, CRO employees and the wide community of other professionals involved in the clinical development process.
  • Maintain a high degree of awareness of new and emerging medical developments, and rapidly and accurately integrate and effectively communicate all sources of data, internal and external, relevant to your project to inform our ongoing research and development.

You will have:

  • An MD degree or equivalent from a recognized school of medicine
  • Specialty training or board eligibility in medical oncology (or a closely allied field)
  • An oncology-focussed PhD
  • Relevant clinical research experience in oncology (i.e. involvement in the design, conduct and interpretation of clinical trials)
  • A track record of being responsive to scientific data, with an ability to demonstrate how you have followed and adapted to emerging science and innovation in your research
  • A collaborative outlook with a natural ability to work in teams and across functions in an environment of peers, along with a flexible and entrepreneurial spirit and a real willingness to roll up your sleeves
  • Strong written and spoken English skills, with the ability to present, write and review technical clinical documents and reports
  • Ability to travel nationally and internationally.

Desirable skills and attributes include:

  • Prior work experience within the pharmaceutical industry, or of working with it
  • Work experience across multiple organizations and geographies

AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Apply now to join us and help us turn ideas into life-changing medicines.

To apply please click the apply button.

Applications Open: 26th May 2017. Applications close: 30th June 2017.

Similar jobs

Similar jobs